PHGY 311 Lecture Notes - Lecture 20: Long-Term Depression, Action Potential, Entorhinal Cortex
6 Nov 2016
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Analysis of locus of expression of plasticity (pre or post-synaptically expressed?: locus of expression of lt plasticity can be assessed indirectly from electro- phgy recordings using 3 analysis methods: If first spike"s ltd is much bigger than the subsequent ones, it"s presyn: change in dynamic, change in std, so change in ppr. If all spikes" ltds are proportionally equal, the it"s postsyn: ex. E2/e1 = n2p2q2/n1p1q1 = p2/p1: n and q are constant for this specific case, p = 1 failure rate, use graph/experiments to count failure rate. Failure rate analysis fails to be useful: if n too big, can"t distinguish individual quanta peaks. Gaussian blur smears the individual peaks: so use quantal analysis (light version, for the exam ) Coefficient of variation (cv) analysis. ( quantal analysis. Lite ) cv = / : = sd standard deviation, = mean. Graph the normalized 1/cv^2 to normalized mean: normalized meaning relative to the starting point (1,1)
