PHGY 313 Lecture Notes - Lecture 16: B-Cell Receptor, Signal Transduction, Antigen
24 May 2016
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Document Summary
Composed of 2 transmembrane glycoprotein chains: alpha-beta or gamma-delta. Extracellular portion of each chain consists of 2 domains like the ig ( fab =antigen binding region) components (cd3 complex) Antigen-binding site of the t cell receptor is similar to that of b cell receptor. No intracellular domain, unlike tlr; has to work with other signaling. Tcr associates with cd3, forming he tcr-cd3 membrane complex. Cd3 is formed by 5 invariant polypeptide chains that associate to form 3. Heterodimer of , heterodimer , and homodimer . Cd3 is required for membrane expression of alpha-beta and gamma-delta tcr. Cd3 = signal transduction via itams (immunoreceptor tyrosine-based dimers: o. Genes that encode all the alpha-beta, gamma-delta tcr are expressed only in t cell lineage cells organization of the ig genes. Chains and v, d, j segments in the , 4 tcr loci ( , , , ), are organized in a germ line similar to multi-gene.
