PHGY 313 Lecture Notes - Lecture 17: Thymocyte, Cd44, Il2Ra

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313-lect 17: adaptive immunity-t-cell mediated immunity: development, activation, effector function. Clp (common lymphoid progenitor) migrates from bone marrow to thymus. T cell precursor goes into dn stage of development dn1, dn2, dn3, and dn4. Acquisition of c-kit, cd44, and cd25 molecules on their cell membrane by the 4. Sequential release of some of these 3 molecules during dn cell differentiation. Rearrangement of gamma-delta locus for functional tcr gamma-delta. Expression of rag proteins, allowing for alpha-beta rearrangement for functional. If beta chain is successful, you get upregulation of cd4 and cd8 then you are in dp. Dp makes a decision to be cd4 or cd8, based on its interaction with mhc. Need upregulation of cd3 five polypeptide chain to make cd3 complex (needed for. **you need rag to promote alpha and beta rearrangement, tdt for diversity** Thymocytes test their tcrs so that they both recognize self-mhc and are not autoreactive surface o o.

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