PHGY 313 Lecture Notes - Lecture 22: Trichuris, Human Parasite, Antigenic Variation
24 May 2016
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Phgy 313-lect 22: immunity against parasites o o o. Top human parasites: ascaris, hookworm, malaria, trichuris, amoeba o o o. Elicits th1 response (cell-mediated immunity with appropriate class switching) Location of parasite shapes the immune response: giardia: o o. In the gut, evades via cysts and immunodepression. Igm, iga, igg: leishmania: o o, entamoeba: o o, trypanosoma: Immune response to helminths: schistosoma: o o, trichinella, ascaris, filaria: o o o o o o. Reduce their own antigenicity by growing within host cells (antigen. Have proteins that look like host proteins, acquire host membrane proteins (antigen mimicry) Caused by 4 species of plasmodium: 1) falciparum, 2) malariae 3) ovale 4) Sporozoites enter the bloodstream and migrate to liver. Immune response to malaria compared to adult"s 84%) o. Children under 14 years have the lowest immune response (22% igg. Igg levels are low from 3 months to 1 year! Most people in endemic areas have lifelong low-level infection.
