PSYC 100 Lecture Notes - Lecture 10: Donald O. Hebb, Synapse, Hebbian Theory

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PSYC 100 Full Course Notes
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PSYC 100 Full Course Notes
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Synaptic connectivity and memory- santiago ram n y cajal (1852-1934: anatomical changes of the connections between neurons as the basis of memory, spine density increases during learning. Spine remodeling during learning - # of spines increases: training increases # of spines in rat"s hippocampus, untrained animals do not show same connectivity in neuron synapses. Synapse: astrocyte process, pre and post synaptic terminals, calcium driven fusion with membrane, sodium can enter neuron, depolarizing it and then it is fired. Ltp may require protein synthesis (translation) and transcription. Ltp induction increase in ampar expression: ltp increases sensitivity of hippocampal neuron to spatially highly restricted (downward arrow) application of glutamate, increase of glutamate response was measured 2 hours after ltp induction. Psd (post-synaptic density) as a complex protein network to implement synaptic plasticity. Synaptic consolidation changes structure of synapses to form memories. Socially transmitted food preference applied up to 5 days after conditioning rats rat colony (temporal gradient in amnesia data)

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