PSYC 211 Lecture 43: 43
16 Mar 2017
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Document Summary
Role of nmda receptors in the ca1 field of the hippocampus, n-methy-d-aspartate (nmda) glutamate receptor plays a significant role in ltp. Now glutamate can open the ion channel and permit the entry of calcium ions. Drugs that block nmda (e. g. ap5) prevent calcium entering the dendritic spines and block ltp. Role of ampa receptors the synaptic strength during ltp is due to ampa receptors (ampa is a glutamate receptor) They are located in clusters at the base of the dendrite spine. When ltp is induced, the ampa receptors flood into the dendritic spines of ca1 neurons (the postsynaptic density) The movement of ampa is caused by a calcium dependent enzyme called type ii calcium- calmodulin kinase (cam-kii) Cam-kii can autophosphorylate; it can attach to a phosphate group to a particular location on the molecule. This allows cam-kii to remain active by itself without the need for calcium. Summary of ltp terminal button releases glutamate which binds to the nmda receptor.
