PSYC 211 Lecture Notes - Lecture 7: Dysphoria, Barbiturate, Blind Experiment
16 Mar 2017
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Dose response curve the magnitude of an effect of a drug as a function of the amount that is administered. It is obtained by giving subjects various doses of drug (according to weight) morphine (administer enough that there is an effect but low enough that there is not a depressive effect) Higher doses cause larger effects until the point of maximum effect the difference between the two curves is the drugs margin of safety. For tolerance, the dose-response curve shifts to the right: require higher doses of the drug for the same effect. For sensitization, the dose-response curve shifts to the left: require lower doses of the drug for the same effect. An instance where the shape of the curve would change is for a chemical class of drugs with similar (if not the same) therapeutic effect with varying efficacies, partial agonists, or allosteric binding.
