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Lecture

13 May 27 2014.docx

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Department
Psychology
Course
PSYC 311
Professor
Michalakis Petrides
Semester
Summer

Description
PSYC31113May272014AreasonprecentralgyrusdonothaveagranularlayerTheyarereferredtoastheagranularmotorareasPeopleoftentalkedaboutintelligentbehaviourdependingontheprefrontalcortexHebbandmanyotherpeoplefoundthatpatientswithveryalrgeexcisionsofprefrontalcortexshowednoimpairmentsonstandardintelligencetestsLargelesionsofprefrontalcortexespeciallylateralcausedsomeinflexibilityinbehaviourWisconsinCardSortingTestwasusedtoshowthisThiswasoriginallydesignedtostudyclassificationNormalsubjectsiftheystartmakingthesekindsofselectionstheysoonrealizewhatthecorrectcategoryisPeoplewithlargefrontallobelesionsoftendopoorlyonthistaskOncetheydiscoverthecorrectcategorywhenyourclassificationchangestheyrestuckonthecategoryTheymightcontinueclassifyingaccordingtocoloureventhoughtheykeephearingthattheyrewrongPatientmightsayIknowitswrongbutwhatelsecoulditbeEventuallytheymaychangebuttheyhavethesameproblemwhentheclassificationchangesagainUsuallyduetoverylargelesionsofdorsalpartofleftprefrontalcortexThistestrevealsthatonceyouhavedamagetoanumberoffrontalsystemsbehaviourbecomesinflexibleYourconceptualbehaviourbecomesinflexibleYoumightfindyourselfstuckontoonewayofbehavingwhichisnolongerappropriatebutyoufindithardtoletgoofpreviouswaysofrespondingNotethatHMisgoodatthistaskThefactthathehasforgottenthepreviouscategoryprobablyhelpshimasitresultsinnointerferenceinhismindThisisausefulclinicaltestWCSTJacobsenremovedtheprefrontalcortexinmacaquemonkeysDelayedResponseTestMonkeystrainedtoperformDelayedResponseTaskDRTMonkeyswithPFClesionsshowdecreasedperformanceSuggeststhatthePFCisinvolvedinworkingmemoryInvolvesputtingfoodinawellholeinfrontofthemonkeyYoucoverbothwellsYoubringthescreendownsotheresadelayLiftthescreenLetthemonkeymakeachoiceNormalmonkeyshavenoproblemwiththisYoucanputitindifferentwellondifferenttrialsPeoplesaidtheimpairmentwashappeningaroundthesulcusprincipalisWhy
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