PSYC 318 Lecture Notes - Lecture 1: Conditioned Place Preference, Montane Vole, Immunohistochemistry
15 Jun 2016
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Nucleus accumbens both glutamatergic and dopaminer c inputs monogamous pair bonding single partner, gestational bond, diparental care, higher otr density in nac. Montane vole polygamous low otr density in nac. Oxytocin social bonding polymorphism sexual behavior, orgasm both as neuropeptide and hormone. Otr antagonist (block all oxy activity) saline (control) Day 2: lock in one room with peers. Day 4: test with free access to both rooms. Reverse-microdialysis and social cpp slow drug di usion into nac. Microdialysis- taking uid up from brain reverse-microdialysis - pushing drug into brain. Immunohistochemistry (ihc) add uorescent tags on proteins using antibodies. Epsc does not generate re of nac neurons. Determ where ltd is coming from look at vesicle release in upstream glutamatergic excitatory neurons. Amplitude: amount post-synaptic receptors with oxy present, we see less in freq, no change in amp this has to be a pre-synaptic e ect sth has to happen in the glutamatergic neurons.
