PSYC 318 Lecture Notes - Lecture 2: Optogenetics, Addiction, Titration
15 Jun 2016
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Cocaine animals do not have this expectation. both sucrose and cocaine animals both have overall increasement in the learning increase in ring in sucrose animal ofc neurons when a and v signals are paired and presented the rst time. Sucrose animals will nally realize the compund signal does not do anything special. Cocaine are unaware at all, cool w anything. Sucrose animals have under-expectation for a signal itself. Cocaine animals have same expectation for a1v and a1. Optogenetic manipylation of ofc activity idea: to manipulate ofc of cocaine neurons and see what will happen under-expectation restores! Controllers of hunger model based: all stimuli are neutral to animal; cannot be used to reinforce or punish behavior i. e. nutritional value of an creme crulee. Pavlovian conditioning: one stimulus is uncoditioned stimulus; in exible; model free. Three energy signals nutrient-related: blood, glucose/ffa short-term: stomach (hormones) long-term: adipose negative feedback (leptin) Ghrelin: stomach derived, hunger signal, increases hedonic value of food.
