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Lecture 6

PSYC 342 Lecture Notes - Lecture 6: Cell Migration, Immunoassay, Radioimmunoassay


Department
Psychology
Course Code
PSYC 342
Professor
Jens C Pruessner
Lecture
6

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PSYC 342 Lecture 6 - Jan. 26
Estrogen and the Aging Brain:
More lost more hippocampus volume early in life compared to women, but at old age, they are near-
ly the same (due to menopause?)
Progesterone Receptors in the Brain:
Hypothalamus
Median eminence
Amygdala
Pituitary gland
Role in female and male sexual behaviours, in females often in conjunction with estrogen
Testosterone Receptors:
Located in the septum, amygdala, hippocampus, hypothalamus, pituitary gland
Hypothalamus and pituitary gland use feedback to regulate and find out how much testosterone is
present; amygdala and hippocampus control emotional feedback
Regulates male sexual behaviour, emotion, motivation, spatial ability
Receptors also bind to dihydrotestosterone
Adrenal Hormone Receptors in the Brain:
Deals with stress and stress regulation
Two types of receptors:
Type I: Mineralcorticoid receptor
Type II: Glucocorticoid receptor
Type I has high affinity for steroid hormones, Type II low
Type I stimulates further hormone release, Type II inhibits
Type I predominantly in the limbic system and hippocampus, Type II throughout the brain
In low levels, Type I will increase to stimulate further activity of the system until a level where
Type II will be activated to inhibit (block); decrease the level until Type I will come back again to
restart the system; oscillation of system
The limbic system will be stimulated at all times because they have receptors with low affinity;
constant input of steroid hormones into limbic system while the rest of the body (including brain)
does not see the glucocorticoid that often
Only at peak activity of the axis will there be a stimulation of non-limbic areas of the brain be-
cause they only have Type II hormones (high stress results in the brain knowing about it)
Thyroid Hormone Receptors:
Only non-steroid hormones which goes into the brain
Located throughout the brain with highest density in the cerebellum, limbic system, brain stem
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