PSYC 342 Lecture Notes - Lecture 17: Maclyn Mccarty, Epigenetics, Central Dogma Of Molecular Biology
2 Apr 2016
School
Department
Course
Professor
Document Summary
Genome=all information required for development and maintenance of organism, it is selectively accesses when and where it"s needed. 1869: first recorded description of nucleic acids (f miescher) 1944: dna oswald avery, colin macleod, maclyn mccarty. 1952: hershey-chase experiments showed dna is what encodes genetic material (not proteins) Kossel and the five bases: adenine, cytosine, guanine, thymine, [uracil (rna)] Dna=two antiparallel and complimentary sequence strands (double helix structure watson and crick 1953) ^^more complex: rna regulates dna and proteins influence rna and regulation of dna. Organized within chromatin structure: two meters of dna in every cell fits in minute nucleus very compact. Compaction: dna wraps around histone proteins to form nucleosomes which forms chromosomes in the nucleus. Dna is functionally organized within the chromatin so accessibility of genetic info is critically important. Nucleosome=fundamental repeated unit of chromatin=histone octamer (two copies of each histone family) + 146 bp dna slides have visuals (also in reading)
