PSYT 301 Lecture Notes - Lecture 7: Opioid Antagonist, Gaba Receptor, Naltrexone
24 Feb 2016
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Document Summary
Rewel: expression of different subunits in the rat brain. Gaba receptor subunit composition varies over different regions implication is that alcohol sensitivity will be different, across various subunits and brain regions. Given the large number of associations between gabaa subunits, coga suggests that the predisposition to alcoholism may be inherited as a general state of cns disinhibition/hyperexcitability due to altered responsiveness to. Gaba polymorphisms may result in impulsivity recent research suggests that gabaa subunit polymorphisms may also affect alcohol reward and responses. Alpha 4 may be related to the heredity of alcohol dependence. Gaba changes may lead to behavioural differences. Solid finding, but mechanism is not unknown, alpha 2 or 4 polymorphisms do not cause alcohol dependence. Impulsive personality can cause people to make rash decisions. Placebo effect and desire to leave ward (or treatment) may alter the effectiveness of drugs. Wanting to please the physician, may lie to maintain relationship with the practitioner.
