PSYT 301 Lecture Notes - Lecture 13: Levamisole, Benzoylecgonine, Piperazine
24 Feb 2016
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Document Summary
New psychoactive substances (nps): designer drugs, herbal highs, synthetic drugs. Mephedrone: similar psychoactive effects to cocaine/other stimulant. Many people that buy cocaine might not even have cocaine in the sample, cut with multiple toxic substances including levamisole (a deworming agent that causes necrosis, aim to mask the adulteration) Mdma or ecstasy is one of the most adulterated drugs, caffeine, others . Normally cocaine is degraded by plasma or liver esterases to benzoylecgonine (50%- Easier to overdose on it -- a lower amount will lead to a 50% death rate increased cardiovascular and subjective effects. Effects vary in the pns, depending on the tissue distribution of alpha and beta adrenergic receptors relax smooth muscle in bronchioles leading to bronchioles dilation, but constrict peripheral blood vessels leading to increased hr and bp. Methamphetamine is more commonly abused due to the fast route of administration (smoking - ~10s), large bioavailability, fat soluble, passes bbb very easily first anti asthmatic.
