ANTHROP 2D03 Lecture Notes - Lecture 4: Single-Nucleotide Polymorphism, Mendelian Inheritance, Dna Replication

• School: McMaster University
• Department: Anthropology
• Course: ANTHROP 2D03
• Professor: Hendrik Poinar

Document Summary

Can occur to the dna of ant cell. This can happen to any sperm/egg cell. Due to replication errors, repair errors, transposable elements, mutagens, etc. The most common reason for a mutation is a replication issue. Only mutation in gamete-lineage cells would be passed to offspring. A change in one basepair of dna to a different nucleotide. Typically occurs during errors in dna replication. Aut i. e. base has changed from c to u in aut. During replication to 3" we see g, so we know it was a c before the mutation. Because we know the original from the other side, we can replicate from the original to get the original. Act gene sequence instead of the mutated aut. Dna replication process cannot recognize rna replication, so it will replicate as act, not. Nonsense = a stop codon (terminates translation) Changing protein (end product) is worse than changing dna. Independent assortment= each chromosome (and genes) is randomly distributed to gametes.