BIOCHEM 2B03 Lecture Notes - Lecture 4: Haematoxylin, Motor Neuron Disease, Eosin
28 Sep 2013
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First identification of stem cells: 1963: canadians jim till and ernest mcculloch prove the existence of stem cells (toronto) Paper: cytological demonstration of the clonal nature of spleen colonies derived from transplanted. Derived cells from bone marrow and identified some characteristics of these cells. Cells had potential to become many types of different cells and undergo mitosis to produce more of themselves (renew self to create another stem cell) and then other cell can differentiate: siminovitch, l. , e. a. Paper: journal of cellular and comparative physiology. Demonstrates that these progenitor cells were capable of self-renewal. Classes of stem cells: embryonic stem cells (pluripotent, adult (or somatic) stem cells (multipotent or unipotent) Inner cell mass; only go on to form embryo; pluripotent (pink) Each cell has potential to become an entire organism: figure: 5 day old, pre-implantation embryo. Inner cell mass: blastocyst 5 days post-fertilization. Outer layer of blastocyst will become placenta and supporting tissues.
