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Lecture 5

Biochemistry 2EE3 Lecture 5.docx

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Karen Mc Garry

Biochemistry 2EE3 Lecture 5 • • • Nucleic acids are polymers • Major function is storage and propagation of genetic information • Just have one copy of DNAtherefore not a high amount of them compared to other molecules • Evidence of primordial RNAworld is that most organisms have DNA/RNA (?) • DNA/RNAcan serve as catalysts, although most are proteins • • Nucleic acids are energy carriers • Must memorize chemical structure of four nucleotides • ATP is based on adenosine nucleotide • 30kJ/mol required to synthesizeATP • Energy comes from repelling of joining of two negatively charged phosphate groups o Bonding energy high, therefore they join o But, if catalyst comes and helps break them apart, they store a lot of energy • • • • Base is donor of H bonds, lone N also accept H bonds – this is most important structural feature of all four bases • • Thymine and uracil are very similar o Identical in H bonding o Uracil is derivative of thymine, present in RNA • Main different between RNAand DNAis minus oxygen, difference in thymine/uracil • • Distance between donors/acceptors inA-T pair, match perfect distance of hydrogen bonds (?) • A-T pair makes two H bonds • G-C pair makes three H bonds • In 99.99% of cases,Abonds with T, G bonds with C o High energy structures of non-complementary base pairs can sometimes occur resulting in mutat
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