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Lecture 14

Biochemistry 2EE3 Lecture 14.docx

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Boris Zhorov

Biochemistry 2EE3 Lecture 14 • • • • • • • Two categories of articles on Wikipedia – basic science reliable, other depends on authors • Vitalism: functions of a living organism are due to a vital principle • • Nothing but physics and chemistry doing on in our cells – biological laws are derived from physics and chemistry • • • We are complex! • • Understand all of diagram! • Overview of energy flow in metabolism • Energy released in several forms of high energy molecules includingATP and coenzymes NADH and NADPH • Goes to anabolism to build energy rich complex metabolites • • • ATP from glycoslysis is important as it is fast, although not a lot • Oxidative phosphorylation gets energy from NADH and FADH2 • Know figure 14-3 • Oxygen used in oxidative phosphorylation to function as • Must know pyruvate chemical formula • Pyruvate is produced as final product of glycolysis and when amino acids and fatty acids are broken down • NADH/FADH are high energy, synthesized during citric acid and produce higher energy after oxidative phosphorylation • • • When burning up glucose, need oxygen • • Energy stored by chemical structure • Phosphate groups are negatively charged • ADP and Pi would normally repel because negative charge, but brou
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