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Biochemistry 2EE3 Lecture 22.docx

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Boris Zhorov

Biochemistry 2EE3 Lecture 22 • • • Not sequential, complex I/II • Complex 2 = FADH 2 • • • • • Electrons from NADH from glycolysis can enter ETC through glycerophosphate shuttle and CoQ picks them up • CoQ can move freely due to hydrophobic tail • • Cytochrome C can only accept one electron at a time • Electrons move from CoQ to complex III: • Electrons from complex I put CoQ in reduced form • Reduced form binds to one portion of complex III, close to Fe-S cluster • One electron transferred to Fe-S cluster • The other electron goes to cytochrome B in complex three • Cytochrome B goes to cytochrome B-H ? • NADH? • Goes back and gives electrons to CoQ, so that it can again be transferred to cytochrome C • The first electron from Fe-S cluster gets transferred to cytochrome C in cluster III then to cytochrome C on inner side of mitochondrial membrane • CoQ can get two electrons because can be in reduced/oxidized/radical form • CoQ can transfer one/two electrons to complex III in two different areas because cytochrome C can only accept one electron, therefore needs mechanism to transfer two electrons onto cytochrome C but one at a time • Each of the electrons from CoQ get passed on to cytochrome C eventually, but individually • • Four cytochrome C’s to reduce oxygen to water • • • T
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