BIOCHEM 4M03 Lecture Notes - Lecture 24: Gestational Age, Intrauterine Growth Restriction, Microvillus
14 Apr 2017
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Biochem 4m03 lecture 24 early life metabolic regulation ii. Driven by placental lactogen, progesterone, microbiota, cortisol, prolactin, estrogen. Increased number of insulin receptors (esp. in adipose tissue) No change or an increase in insulin receptor binding. A marked reduction in insulin stimulated insulin receptor autophosphorylation and tyrosine kinase activity in liver but not in skeletal muscle. Reduced insulin-induced tyrosine phosphorylation of irs-1, p85/irs-1 association and phosphorylation of akt1 and 2. Inhibit insulin signaling between akt and glut4 translocation. Suppressed insulin-induced glut4 translocation without affecting total protein amounts of glut4. It is phosphorylation and autophosphorylation of tyrosine kinase activation that might be changed with high doses of progesterone that occur with pregnancy. Regulators of fetal growth: genetics, nutrition, endocrine. Genetics plays a very small role in fetal growth. The only factors that significantly influenced birth weight were gestational age and recipients" weight. Nutrient availability (reduction in nutrients that will limit fetal growth: may be demand driven.
