BIOCHEM 4M03 Lecture Notes - Lecture 26: Fetal Circulation, Insulin Resistance, Catabolism
15 Apr 2017
School
Department
Course
Professor
Document Summary
Biochem 4m03 lecture 26 - maternal undernutrition. Low birth weight and iugr are not the same thing. Poor blood flow (reduction in blood flow) In twins, often one twin is larger: fetus. Blood flow one of mediators of fetal growth. Pregnant with twins, triplets or more: why does more than one baby = lbw maternal constraint! Socioeconomic factors: quality of healthcare, better supplementation, micronutrients you may not be getting in your diet, higher stress lifestyle (higher maternal cortisol), higher fat diet (fetus growing off processed foods), knowledge base. Intrauterine growth restriction (iugr) occurs through: uteroplacental blood flow reduction (reduction in maternal cardiovascular function, abnormal villi development/structure/function. Human pregnancy: uterine flow increases from 60ml/min to 700-800ml/min throughout pregnancy. Flow rate to uterus increases from beginning to end: maternal blood flow to uterus. Placental vascular resistance in iugr sheep fetuses decrease in blood flow. Surface area is reduced in human iugr in conjunction with changes in villi development and function.
