BIOCHEM 2EE3 Lecture Notes - Lecture 11: Fatty Acid Metabolism, Pyruvic Acid, Hmg-Coa Reductase
16 Apr 2018
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Document Summary
Our body needs healthy fats like omega-3 fatty acids. Must be from our diet to regulate blood pressure. Also not all saturated fats are bad - ex. The breakdown of fats (triacylglycerols), ketone bodies, and some amino acids can lead to acetylcoa. Triacylglycerol is the storage form of a fat (aka triglycerides) Made of 3 fatty acids, which have been esterified with a glycerol. Lipase enzyme can release the free fatty acids from the glycerol. Muscle might have a little fat stored too. Stimulates lipase to breakdown fats to provide energy. Via beta-oxidation, the free fatty acids get broken down and oxidized to produce nafh and fadh (reducing equivalents) as well as acetylcoa which can feed into citric acid cycle to generate energy in gtp form and more reducing equivalents. Process - fate of the fatty acids (1) fatty acids which were released by lipase leave adipose tissue and enter bloodstream to get delivered to tissues to produce energy.
