BIOCHEM 2EE3 Lecture Notes - Lecture 9: Hexokinase, Blood Sugar, Citric Acid
17 Apr 2018
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Introduction: glucose is broken down through glycolysis, pyruvate dehydrogenase reaction and citric acid cycle. Utp as energy to drive this reaction forward: like atp, utp can be used as a energy source. Glycogen synthase and glycogen phosphorylase activity: some enzymatic reactions in metabolism are very tightly regulated and controlled. It is so that futile cycling is not occurring, such as glycogen breakdown occurring simultaneously with glycogen synthesis. Allosteric regulation of glycogen synthase and glycogen phosphorylase. In glycogen phosphorylase, phosphorylation by an enzyme called a kinase converts it to its active form: removal of phosphate group by an enzyme called a phosphatase concerts it back to its inactive form. Module 9 video 1: glucagon and epinephrine stimulate phosphorylation by the kinase. Insulin is released in response to elevated glucose levels in circulating in the bloodstream following a meal. Control of flux through glycolysis: step 1 is catalyzed by the enzyme hexokinase.
