BIOCHEM 2EE3 Lecture Notes - Lecture 7: Procollagen-Proline Dioxygenase, Scleroprotein, X-Ray Crystallography

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Human genome contains about 26,000 genes but the protein number depend on the cell type and what they do. Primary structure of a protein is the amino acid sequence of its polypepide chain. Protein have tens to thousands of amino acid residues. 100 amino acid residues may be combine in 20100: the universe has about 1079, 20 is the base; since we have 20 diferent amino acids charged amino acids behave like hydrophilic amino acids. The primary structure determines the properies of a protein, while the amino acid composiion is relaively not important. Each protein consists of one or more polypepide chains. Helical structure is the most stable secondary structure. In quaternary structures the polypepide chains are not held together by covalent bonds, instead they are linked by weak vanderwals or hydrophobic bonds to form stable structures. What determines inal 3-d shape in protein: it depends on the primary structure (by the amino acid sequences)

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