BIOCHEM 4M03 Lecture Notes - Lecture 7: Growth Factor, Pyruvic Acid, Glycogenesis
1 Feb 2017
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Biochem 4m03 lecture 7 glycogenolysis and gluconeogenesis. Allosterically inhibited by presence of high amounts of fatty acids (palmitoyl-coa) Both acc1 and acc2 isoforms convert acetyl coa to malonyl coa. Generation of acc1ser79ala & acc2der212ala knock-in (ki) mice. By changing it to an alanine, preventing it from being phosphorylated. Found that the knock in mice didn"t have the ability to be phosphorylated, acc1 and. Much higher levels of malonyl coa in hepatic lipogenesis. Glucose oxidation was higher, fat oxidation was lower. Enzymes had a constant high glucose flux into system. Acc phosphorylation is required to prevent liver lipid accumulation. Phenotype of these animals develop resistance to insulin. Loading of sulfhydryl groups into the fatty acid synthase system. Malonyl coa and acetyl coa are condensed, combines both to generate fatty acids. The steps in the synthesis of fatty acid. Ce (condensing enzyme) and acp (acyl carrier protein) are members of a complex of enzymes referred to as the fatty acid synthase system.
