BIOCHEM 4M03 Lecture Notes - Lecture 12: Thermoregulation, Pyrrole, Atp Synthase

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Biochem 4m03 lecture 12 the role of serotonin in metabolic disease. Beige fat is a new kind of fat discovered (half brown half white: oxidative fat within our white fat. Mouse doesn"t" need to generate heat in order to stay warm: 28 degrees white fat, white depots turns brown in 6 degrees. Means there is plasticity in our adipose tissue to maintain thermoregulation. Generating h ions which accumulate in intermembrane space. They travel back through atp synthase and get generation of atp. What makes brown and beige fat unique is that it contains this uncoupling protein. It decouples hydrogen ion to pass through atp synthase, allows them to flow through space without atp: analogy: this morning woke up cold and go to thermostat and press 21 degrees, furnace detects signal and turns on. Uses small amount of gas, switches on, quickly gas gets burned and the temperature of your house goes up.

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