BIOCHEM 4M03 Lecture Notes - Lecture 16: Macrophage, Glucagon, Saturated Fat
1 Mar 2017
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Document Summary
Inhibition of glucose oxidation due to excess fatty acid and vice versa. Insulin levels are quite high (hyperinsulemia is a marker of insulin resistance) Post receptor defect, suppresses glucose production by liver. Stress in the system: ser kinases phosphorylate intermediates in pathway causing signal defect. Increased lipids, accumulation in cell activating stress kinases. Insulin resistance: obesity is the largest predictor, post-receptor defect in insulin signalling/action (generally, decreased glucose uptake and excessive glucose production. Stress kinases are part of the immune system. Have to match insulin sensitivity to insulin secretion. As long as you"re on this line, you can match it. Type i diabetics are somewhere along x-axis (right graph above) Compensation body compensates by producing more insulin. Generally think of this due to obesity over the years. Progressive increase in insulin resistance, all depends on the stress. Inflection point system fails; blood glucose starts to rise when you can"t match sensitivity to secretion.
