BIOCHEM 4M03 Lecture Notes - Lecture 28: Insulin-Like Growth Factor 2, Agouti Gene, Placental Insufficiency

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Biochem 4m03 lecture 28 epigenetics and interventions. Transgenerational effects of prenatal exposure to the dutch famine on neonatal adiposity and health in later life: impacts are trans-generational, adult offspring (f2) of prenatally exposed f1 fathers had higher weights and. Bmis than offspring of prenatally unexposed f1 fathers. Transmitted through paternal pathway, the adult offspring (grandchildren of initial women) of prenatally exposed f1 fathers. High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring: mammary tumorigenesis is higher in daughters and grand-daughters of high fat fed rat mothers. Really good paper, read it (not tested on it though) Germ cells are key in understanding how these pathways are potentially regulated and transmitted across generations. Peri-conceptual = around the time of conception. In a mouse: around 10-13 days of gestation can already start to modify things. Under normal circumstances, epigenetics regulate cell differentiation.

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