BIOLOGY 1A03 Lecture Notes - Aminoacyl Trna Synthetase, Rna Polymerase Iii, Aminoacyl-Trna

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BIOLOGY 1A03 Full Course Notes
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BIOLOGY 1A03 Full Course Notes
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The first step in converting genetic information into proteins is the synthesis of a messenger rna version of the instructions archived in dna. Enzymes called rna polymerases are responsible for synthesizing mrna. Like dna polymerases, an rna polymerase performs a template-directed synthesis in the 5" 3" direction. Unlike dna polymerases, rna polymerases do not require a primer to begin transcription. Transcription occurs when rna polymerase matches the base in a ribonucleotides triphosphate with the complementary base in a gene (a section of. Dna that codes for a protein or rna) Once a matching ribonucleotides is in place, rna polymerase catalyzes the formation of a phosphodiester bond between the 3" end of the growing mrna chain and the new ribonucleotides. As this matching-and-catalysis process continues, an rna that is complementary to the gene is synthesized. Only one of the two dna strands is used as a template and transcribed, called the template strand.

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