BIOLOGY 1M03 Lecture Notes - Lecture 6: Mns Antigen System, Genotype Frequency, Null Hypothesis
15 May 2017
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Document Summary
Most human population have two co-dominant alleles for the mn blood group. Gene that governs the expression of blood (mn locus) Since the genotypes at the mn locus are similar to the hwe we can conclude that the factors (selection, drift, migration, mutation, biased mating) do not substantially affect the genotype frequencies. This does not mean that mn blood types have always been in hwe. One generation of random mating can generate hwe genotypes for an autosomal locus (a gene not located on the sex chromosomes) Only 2 ways to depart from hwe, either too many heterozygotes or too few or too many or too few homozygotes. We do not prove null hypothesis we either reject or approve the null hypothesis. Another point worth noticing is that allele frequencies of different human populations are different. This is suggestive of population structure between localities even though mating within localities appear within a locality.
