BIOLOGY 2B03 Lecture Notes - Lecture 4: Threonine, Amine, Asparagine

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Hydrophilic amino acids - water soluble therefore find hydrophilic amino acid residues on the exterior of soluble cytosolic proteins: water soluble molecules have portions that charged polarized and capable of forming hydrogen bonds. Charged (ionized) at ph 7 (physiological) o molecules with an oh at one end (o-) o molecules with an nh2 at one end (nh3. Amino acids with positively charged side chains o lysine and arginine. Amino acids with negatively charged side chains o aspartic acid and glutamic acid. Lysine, arginine, aspartic acid, and glutamic acid are the amino acids that are the prime contributors to the overall charge of a protein or a domain of a protein. Threonine and serine o have polar oh groups that can participate in. Asparagine and glutamine o uncharged but have polar amine groups. Cysteine is able to form covalent bonds with other cysteine residues o covalent bonds are called disulfide bridges or cysteine bridges.

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