BIOLOGY 2B03 Lecture Notes - Lecture 2: Cold Shock Response, Protein Folding, Atp Hydrolysis
10 Apr 2018
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When else do proteins unfold/misfold: hsp expression increases during aging and in mouse model systems of degenerative disorders (i. e. alzheimer"s and. Huntington"s: during aging lots of proteins midfold/unfold= hsp expression increases during these times proteotoxic stresses, these are stresses that increase the fraction of proteins that are in an unfolded state. Hsp protect against stress: when more favorable conditions return hsps are down regulated, we evolved efficient system to deal with stress, actually been proven to increase survival, when embryos were given extra hsp copy they had a higher. Anfinsen"s dogma: due to thermodynamic molecular forces, polypeptides automatically assume unique, stable conformations, every sequence of aa auto-assembles into a unique, defining conformation, there are exceptions to this. What is going on inside chaperonin: inside appears to have unique chemical environment"- j. Prediction= mimicking atp hydrolysis closes lid and allows release.
