BIOLOGY 2B03 Lecture Notes - Lecture 12: Molly Mcguire, Transmembrane Protein, G Protein–Coupled Receptor

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 2B03
• Professor: Suleiman A Igdoura

Document Summary

), when food is abundant the amoeba divide using mitosis. When starvation kicks in a series of events lead to aggregation, in response to production of camp by the starved amoeba, of the unicellular amoeba. Aggregated cells form a migrating multicellular collection called a slug, then the slug finds a nutrient rich environment. The slug stops and its cells begin to differentiate, the anterior forms the stalk and the posterior forms the fruiting body containing spores. The spores stay dormant, until food is available and the spores germinate to form new single celled amoebae. The receptor for camp is a transmembrane protein called a g-protein coupled receptors/gpcr, the extracellular domain binds specifically to camp, which activates the receptor. In response the cells reorganize their intracellular actin network to move towards the source of the signal. Signaling initiates actin reorganization including, nucleation, polymerization and depolymerization to enable movement polymerization and depolymerization to enable movement.