BIOLOGY 2B03 Lecture Notes - Lecture 8: Tight Junction, Cell Adhesion, Selectin
13 Dec 2013
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Essential for evolution of multicellular organisms because the interactions allow specialized cells to attach and to recognize one another allowing for tissues to form and perform a specific task. All our cells are proliferating and dividing and differentiating so that like cells recognize one another and contact each other. Molecules involved in any cell adhesion action are called cams (cell. Adhesion molecules); allow cells to segregate into distinct tissues: cadherins, ig family, integrins, selectins. After aggregation, cells form specialized cell junctions: these stabilize cell-cell interactions, promote communication between adjacent cells. Junctions facilitate stable association between cells and allow. Leukocytes: granulocytes: contain toxins for killing pathogens, neutrophil, eosinophil, basophil granulocytes, monocytes (macrophages): phagocytosis, lymphocytes, nk cells lysis of virally infected cells and tumor cells, t and b cells immune response (undergo extravasation) Overview of extravasation process: 5 steps: leukocytes are captured: there is transient association with the endothelial wall.
