Class Notes (839,626)
Canada (511,431)
Biology (2,437)
BIOLOGY 2C03 (138)
Kim Dej (45)

Neurotransmitter Release

1 Page

Course Code
Kim Dej

This preview shows half of the first page. Sign up to view the full page of the document.
Outline of Lecture 14 (02-21 A; Pevsner) Neurotransmitter Release I. Introduction ++ - Role of synaptic vesicles: release nxt onto presynaptic membrane upon stimulation (Ca ), in a way relatively autonomously from cell body - SV lifecycle: SV formation (direct endocytosis or endosomal), nxt loading, docking, priming, fusion, endocytosis (and possible delivery to endosomes) II. Composition of synaptic vesicles - See p. 5 for list of SV properties (size and composition) - There are lots of proteins and subtypes involved in SV, we will focus on a key few - Major functions of SV proteins - localization in nerve terminal: e.g. synapsins, Rabs - transport across SV membrane: e.g. pumps, transporters, SV2 - docking and fusion: e.g. VAMP, synaptotagmin III. General model of vesicle docking and fusion A) 7S complex - Made of synaptotagmin and VAMP on vesicle and synatxin and SNAP-25 on synapse - Forms a very tight complex in a 4-helix bundle - A model proposed in 1994 implicates these proteins as central to membrane fusion B) The other complexes
More Less
Unlock Document

Only half of the first page are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.