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BIOLOGY 2C03 (138)
Kim Dej (45)
Lecture

Monoamines II I

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Department
Biology
Course
BIOLOGY 2C03
Professor
Kim Dej
Semester
Fall

Description
Outline of Lecture 22 (02-25 A; Baraban) Monoamines II I. Dopamine - Synthesis: Tyr  DOPA  DA via Tyr-H and DβH (see Monoamines I) - DA is directly transported into vesicles, released onto DA receptors (5 types), and inactivated by reuptake (a target of cocaine) - Evidence for DA as a nxt: Tyr-H /DβH cells, distinct mechanism for DA release/ reuptake/reception, Parkinson’s dz has selective loss of DA neurons II. Serotonin - Synthesis: Trp  5-OH-Trp  5-HT (aka serotonin) via Trp-H, AAD - 5-HT is directly transported into vesicles, released onto 5-HT receptors (>14 types), and inactivated by reuptake - Serotonin is a nxt and also involved in vascular tone - LSD is a mimic of 5-HT; Prozac is a serotonin-specific reuptake inhibitor (SSRI) III. Anatomical distribution of NE, 5-HT, DA: widespread influences throughout brain
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