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BIOLOGY 2C03 (138)
Kim Dej (45)
Lecture

Synaptic Plasticity

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Department
Biology
Course
BIOLOGY 2C03
Professor
Kim Dej
Semester
Fall

Description
Outline of Lecture 28 (02-26 D; Baraban) Synaptic Plasticity I. Long term potentiation - LTP is the phenomena that the peak excitatory post-synaptic potential (epsp) to low-frequency input is greater after a high-frequency input (tetanus), and that this effect persists for a long time - Of presyn, postsyn, or both, most people believe postsyn changes mediate LTP - LTP is a bistable switch toggled by NMDA - AMPA receptors require Glu for to open and do not allow Ca flux - NMDA receptors require Glu and depolarization to open and allow Ca flux - Mechanism of toggling: tetanus  prolonged depol.  AMPA nad NMDA opens  Ca flux due to NMDA  signals for insertion of more AMPA receptors  greater postsyn depol in future - “Silent” synapses with no AMPA can still undergo LTP if NMDA receptors are still present at synapse and if surr
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