BIOLOGY 2C03 Lecture Notes - Classical Conditioning, Synaptic Plasticity, Excitatory Postsynaptic Potential
28 Jan 2013
School
Department
Course
Professor
Document Summary
Ltp is the phenomena that the peak excitatory post-synaptic potential (epsp) to low-frequency input is greater after a high-frequency input (tetanus), and that this effect persists for a long time. Of presyn, postsyn, or both, most people believe postsyn changes mediate ltp. Ltp is a bistable switch toggled by nmda. Ampa receptors require glu for to open and do not allow ca flux. Nmda receptors require glu and depolarization to open and allow ca flux. Mechanism of toggling: tetanus prolonged depol. Ampa nad nmda opens ca flux due to nmda signals for insertion of more ampa receptors greater postsyn depol in future. Silent synapses with no ampa can still undergo ltp if nmda receptors are still present at synapse and if surrounding synapses provide depol. for nmda activation. Input specificity: only synapse receiving tetanus gets ltp.
