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BIOLOGY 2C03 (138)
Kim Dej (45)
Lecture

Pain I

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Department
Biology
Course
BIOLOGY 2C03
Professor
Kim Dej
Semester
Fall

Description
Outline of Lecture 29 (02-27 A; Johnson) Pain I Some stuff in notes arbitrarily hacked out in preference for material covered in lecture! I. Basic properties of nociception - Pain is like other sensory modalities, but it is unpleasant (affective component) and intense pain as an invariant negative response - There are three types of pain: cutaneous pricking, cutaneous burning, and deep visceral, with differing characteristics - Hyperalgesia is a lowering of pain threshold in response to tissue injury - Primary hyperalgesia is located at site of injury, and is due to Aδ fibers - Secondary hyperalgesia is located in tissue around the injury, and includes referred pain - Central sensitization (increased responsiveness of central pain neurons to input) plays a role in both types of hyperalgesia - Neuropathic pain results from an injury to the parts of the nervous system that determine pain - Thermal threshold for pain is constant (45°C), but mechanical threshold is variable - Inflammation stimulates and sensitizes area to pain, a protective mechanism - Larger, faster Aδ fibers mediate pricking pain; smaller, slower C’
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