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BIOLOGY 2C03 (138)
Kim Dej (45)
Lecture

Molliver) Reward

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Department
Biology
Course
BIOLOGY 2C03
Professor
Kim Dej
Semester
Fall

Description
Outline of Lecture 73 (03-31 B; Molliver) Reward You might want to review Lectures 22 (Monoamines II) and 51 (Basal Ganglia). Effects of stimulant drugs is the focus of this lecture I. DOPAMINE - Dopamine neurons are found in ventral tegmentum (midbrain) - Basic structure of a basal ganglia loop is the same for neocortex and limbic system - Neocortex  dorsal striatum (caudate)  globus pallidus  VA thalamus  neocortex - Hippocampus  ventral striatum (nucleus accumbens)  ventral pallidum (substantia innominata)  MD thalamus  anterior cingulate/orbitofrontal cortex - The basal ganglia provides the connection between limbic system and dopamine neurons - Recall from basal ganglia lecture that DA neurons from ventral tegementum area project to striatum and substantia nigra; therefore DA neurons can affect the limbic system through its basal ganglia loop - DA neurons exert their effects by modulating postsynaptic response to Glu (D1 facilitates, D2 inhibits) II. SEROTONIN
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