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BIOLOGY 2C03 (138)


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Bhagwati Gupta

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Biology/Mol.Biol. 2CO3: Genetics Fall 2013 INSTRUCTORS: Dr. Nicole Robbins, Ph.D. BSB 201A [email protected] Office hours: Monday and Thursday 12:30 – 1:30 pm Dr. Bhagwati Gupta, Ph.D. LSB 330 [email protected] Office hours: TBA Instructional Assistant: Dr. Mihaela Georgescu LSB 119A [email protected] Office hours: Monday through Friday 10:00-11:30 am and 1:00-2:00 pm, or whenever the door is open. LECTURES: JHE/376 Monday, Thursday 3:30-4:20 pm Tuesday 4:30-5:20 pm COURSE DESCRIPTION: An understanding of the principles of Mendelian inheritance is a prerequisite to the conceptual understanding of all fields of Biology. The material covered in this course builds upon topics covered in first year Biology, which was an introduction to heredity and the molecular biology of information transfer from DNA to RNA to protein. We take a more detailed examination of how traits are transmitted and how a genotype is expressed as a phenotype. We also explore aspects of chromosomal mapping, linkage, crosses, and mutations and begin to look at genome mapping projects and the application of information from the genome. We also take a look at genes and alleles at the population level and discuss factors that change allele frequency. We also take a close look at polygenic traits, those traits that are determined by multiple genes which include plant growth, human height, and disease. Underlying our examination of inheritance and the expression of phenotype is an understanding of the molecular mechanisms that regulate gene expression. COURSE OBJECTIVES: By the end of this course students should be able to, •define and solve genetics problems that include data interpretation and problems of statistics and probability. •interpret, analyze and design scientific experiments •demonstrate verbal communication skills through regular discussions •students will develop a scientific attitude towards research and data gathering by practicing the scientific methods: formulation of a hypothesis, experimental testing of predictions. PREREQUISITES: Biology 1A03, Biology 1MO3 and Chemistry 1AA3 and registration in an Honours program in the Faculty of Science, or a program in Arts & Science, Health Sciences or Kinesiology. FORMAT: This course consists of three one-hour lectures and one hour tutorial each week. In the tutorial, lecture material, new material, and assignments will be addressed. Therefore, the tutorials represent an integral part of the course work and are mandatory. The penalty for late assignment is 10% per day. This course uses Avenue to Learn to post the course outline, assignments, and other notices. Go to to log-on to the course’s home page. Requirements: Textbook: We will make reference to the following textbook in lecture and tutorial: rd th Genetics - A Conceptual Approach, 3 or 4 edition. Author: Benjamin Pierce Publisher: W. H. Freeman. Note: In lieu of this, you could use a comparable Genetics textbook for reference and practice problems. Newbyte license fee receipt – more information on Avenue. COURSE EVALUATION: Midterm 35% Tutorial quizzes 6% Tutorial assignments (2) 17% Participation 2% Exam 40% SCHEDULE OF LECTURE MATERIAL: Week 1 – Dr. Robbins th th Sept. 9 - 13 What is a gene? Mendelian genetics Case study: Sickle cell disease and the β-globin gene Week 2 –thr. Rothins Sept. 16 – 20 Individual to populations: Population Genetics Case study: β-globin alleles and malaria Week 3 – Dr. Robbins Sept. 23rd- 27 th Extensions of Mendelian principles: Genetic interactions Case study: cat coloration Week 4 – Dr. Robbins Sept. 30th– Oct. 4th From multiple genes to quantitative traits Case study: Plants to humans Week 5 – Dr. Robbins th th Oct. 7 - 11 What is a chromosome? Chromosomal basis of inheritance Case study: Non-disjunction Week 6 – Dr. Robbins First tutorial assignment – Oct. 18 that 4:00 pm th th Oct. 14 - 18 Chromosome dynamics: Chromosomal basis of inheritance Case study: The X-chromosome Week 7
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