BIOLOGY 2C03 Lecture Notes - Allele-Specific Oligonucleotide, Southern Blot, Haemophilia B
5 Nov 2013
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The relative location of genes or loci along a chromosome. Map units are proportional to base pairs. Types of maps which are related (collinear) Salivary gland in drosophila replicate many times but chromosomes do not segregate. Puffs = more accessible regions to factors. Actual bases of dna that you would obtain by sequencing the chromosome. Distance between the genes measured by the number of bases. Relationship is unique to the organism in which map units are proportional to the base pairs distances are not the same in other organism. Genome map: comes from linkage, cytological, and physical maps in situ can also give us chromosome maps. Labeling dna and hybridize with the dna you are studying to locate genes that correspond to the probes. Does not give information of gene localization. Recombination analysis of x-linked genes (limited application) Little information available for distance between human genes. Recombination that segregates the two markers are the most important in a cross.
