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Lecture

Cytoskeleton

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Department
Biology
Course
BIOLOGY 2D03
Professor
Laura Parker
Semester
Fall

Description
Cytoskeleton • Cytoskeleton is made up of 3 dynamic filament systems o Microfilaments  Fxn  structural, mechanical, support myosin-based contractility and motility  Actin monomers  One-start left-handed helix or two-start right handed-helix; polar  ATP as energy source o Intermediate filaments  Fxn  Long distance transport, mitotic spindle signaling  Alpha/beta tubulin dimmers, gamma/beta dimmers  11-15 protofilaments form hollow tube, polar  GTP as energy source o Microtubules  Fxn  structural, mechanical  Lamins, keratins, neurofilament proteins  Coiled-coil dimmers assemble into flexible, nonpolar polymers
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