Class Notes (834,242)
Canada (508,433)
Biology (2,437)
Lecture

CELL CYCLE

4 Pages
131 Views
Unlock Document

Department
Biology
Course
BIOLOGY 2D03
Professor
Laura Parker
Semester
Fall

Description
CELL CYCLE – approx 22 hrs Tightly regulated Basic Requirements: 1. cell size doubles 2. chromosomes replicate 3. MTOC replicates  SPINDLE 4. chromosomes equally distribute 5. cell must divide (cytokinesis) INTERPHASE: G 1 can decide to go quiescent (G )0or move on to S or DIE major decision-making phase: nutrients growth factors signals from other cells G 0 effectively have exited the cell cycle; no longer proliferating S – DNA replication amt of DNA in cell populations can be quantitated by FACS G 2 prepares for mitosis; tetraploid state monitoring step cell enlargement MITOSIS (M) spindle assembles chromosomes condense MT’s disassemble nuclear envelope MT’s grab chromosomes (motors at KINETOCHORE) kinetochore capturing is monitored as a checkpoint cytokinesis waits for full separation **Embryonic Cell Cycle: S and M phases only** Prophase: MTOC separates chromosomes condense Prometa: NE breaks down chromosomes captured (mutlipled MT’s/chromosome) Metaphase: chromo. line at equator Anaphase A: separate chromosomes (DYNEIN (-) motors walk along MT’s) Anaphase B: centrosomes separate (MT’s slide against each other) Telophase: cleave furrow prominent Cytokinesis CELL CYCLE BIOCHEMISTRY Cyclin – Dependent Kinases (CDK’s) drive cell cycle by phosphorylating downstream proteins own cyclin is degraded after next step occurs  cyclin levels rise and fall thoughout cell cycle cyclins activate and help determine CDK substrate specificity their binding enables ATP binding Cyclins destroyed by proteolysis (ubiquitin-directed) Complexes: each composed of different cyclin and different CDK combination G 1DK G 1 S CDK: promotes S phase from G 1 S CDK M CDK
More Less

Related notes for BIOLOGY 2D03

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit