BIOLOGY 2D03 Lecture Notes - Fibrocartilage, Ossification, Osteocyte
28 Jan 2013
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Functions: mechanical support defense (phagocytic cells roam conn. tissue) communication (substrate for blood vessels, nerves) Fibroblasts lay down collagen in direction of migration lay down other components of ecm proliferate after tissue damage. White fat cells store lipids as energy reserve secrete regulatory molecules; production controlled by hormones. Brown fat cells rich in mitochondria heat-generative (short-circuits the electrochem. gradient energy dissipates as heat) Mast cells histamine secretion in response to allergen binding. Immigrant cells see blood lecture from hematopoietic stem cell. Components: secreted by chondrocytes (attach to hyaluronic acid; attract water) Chondronectin enhance chondrocyte-collagen binding (3d network) avascular nutrients arrive by diffusion through perichondrium (c. t. ) anaerobic respiration. Fibrocartilage tough and deformable; interverterbral disks, muscle insertion sites. Interior/interstitial chondrocytes in lacunae divide and secrete cartilage limited capacity for repair, but responsive to gf"s in vitro. Intramembranous ossification mineralization of the osteoid (remodeling) replaces loose conn. tiss. osteoblasts secrete collagen trabeculae woven bone bone.
