BIOLOGY 2D03 Lecture Notes - Lyase, Citrulline, Arginine
28 Jan 2013
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Amino acids degraded to ammonia (passes through urea cycle) and carbon skeletons (enter tca as a-keto acids and exit as oaa) Different type of storage as compared to glycogen and fat. Synthesis of proteins not directed by aa conc. Protein complementarity need all proteins in right proportion. Nitrogen balance positive during growth, pregnancy, recovery negative during malnutrition, metabolic stress, trauma, illness. Ammonia typical levels are 30-60 um death above 150 um sol"n: alternate nitrogen carriers: alanine, glutamine rapid transport urea cycle to convert excess nitrogen to urea urinary excretion of urea. Digestion: proteins cleaved to individual aa"s in small int. 5 transport systems to get aa"s out of lumen neutral, small neutral, large pro/gly basic acidic fate: new protein synth. gluconeogenesis (if no sugar in diet) fat conversion (high sugar diet) Aat aspartate amino transferase uses pyridoxal phosphate to take off amino group from aa from vitamin b6 pyridoxal phosphate puts amino on an alpha-keto acid oxaloacetate aspartate pyruvate alanine.
