BIOLOGY 2D03 Lecture Notes - Endergonic Reaction, Enzyme, Succinyl-Coa

30 views3 pages

Document Summary

Citric acid cycle: citrate synthase conf. change of cs. Coa + citrate irreversible; point of regulation: aconitase. Citrate isocitrate: dehydration (makes db, hydration over db, isocitrate dehydrogenase. Dehydrogenase (very sim. to pdh: succinyl coa. Nadh generated energy from breaking thioester bond to coa trapped in formation of. Fadh2 produced and sent to elec. trans. chain (coq) Malonate inhibits rxn stereospecific hydration across a db. Nadh generated; endergonic reaction that favors product side and is strongly inhibited by presence of excess product (nadh) reaction is only driven forward by next step (catalyzed by cs) Pdh to make acetyl coa regulation of following steps by controlling substrate availability. Cs sensitive to energy charge activation: adp deactivation: atp, citrate, succinyl coa, fatty acyl coa"s. Icdh highly sensitive to atp, nadh inhibition (always off in liver) activated by ca, adp, amp (muscle constraction) akgdh activated by ca inhibited by succinyl co-a, nadh (products)