BIOLOGY 2D03 Lecture Notes - Lipogenesis, Cori Cycle, Phosphofructokinase
28 Jan 2013
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Prolonged exercise new glucose largely made from protein; some from glycerol all blood glucose goes through the liver. Gluconeogenic (kidney also) glucogenic substance: converted to glucose detected in urine after phlorizin treatment (lowers renal threshold for glucose) enzymes: glucose 6 phosphatase. Pyruvate carboxylase (er membrane, faces lumen) (cytosol) (cytosol) (mito matrix) requires 4 atp, 2gtp to go from 2 pyruvate glucose. Pyruvate pep mito: pc pyruvate + hc03 oaa. Acetyl coa: allosteric activator present in high quantities during fatty acid oxidation requires atp adp involves biotin-carboxy intermediate; ping pong rxn flips between bc (biotin carboxylase site) and ct (carboxyl transferase) cyto: pepck. Oaa + gtp pep + co2 + gdp. Oaa decarboxylated, phosphorylated txnally regulated camp, glucocoriticoid activates txn insulin inhibits txn. Mobilization of muscle protein: protease: cleaves into individual aa"s transamination: aa"s a-keto acids consolidation of all into gln, ala. Acetyl coa inc pc activated oaa generated. Nadh inc oaa reduced to malate .
