BIOLOGY 2EE3 Lecture Notes - Lecture 1: Louis Pasteur, Microbial Metabolism, Homocysteine
4 Dec 2017
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3 organismal domains: bacteria, archaea, eukarya. Importance of microbes: environment, humans, microbial diseases, all organisms have common biomolecules and metabolism, origin and evolution, microbial metabolism and ecology. Microbes interact with humans, food, plants, rocks. Aid in food and beverage preparation (fermentation) Look up you tube: cow stomach rumen fluid. Only organisms that can synthesize vitamin b12. Vitamin b12 (cobalamin): water-soluble, key role in the normal functioning of the brain and nervous system, formation of blood, contains the biochemically rare element cobalt (co) Human b-12-dependent enzymes are: methylmalonyl co-enzyme a mutase, 5-methyltetrahydrofolate-homoxytseine methyltransferase (methioninie synthase) Lack of b12 results in: build up of substrates for these enzymes (i. e. , methylmalonic acid and homocysteine respectively) People used to believe that disease was associated with angry gods or bad air. Even when microbes were known to exist, people thought they could spontaneously form as life from nonliving matter.
