BIOLOGY 3P03 Lecture Notes - Lecture 19: Pyruvic Acid, Hemolymph, Cecum
28 Dec 2017
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Recall the br nsted-lowry theory : acids can donate a portion (h+, bases can accept an h+ Typical values of phi (intracellular ph) and pho (extracellular ph) in various tissues are as follows: Is h+ in electrochemical equilibrium inside cells: consider typical values for the membrane potential at rest, say ~ -80 mv, recall: [h+] = 10-ph, eh = 58 log ([h+o] / [h+i]) = -2. 32 mv (in the brain) In other words, cells must expend energy to transport h+ out of the cell or take up base (which are equivalent) Because cellular metabolism produces h+ : aerobically- kreb"s cycle reactions in mitochondria, anaerobically- conversion of glucose to lactic acid (lactate pathway in skeletal muscles)- i. e. metabolic acidosis. Glucose is converted to pyruvate via glycolysis (producing 2 atp and 2 nadh)- The 2 nadh donate electrons to produce 2 lactate. [ion]lumen = vi - vref: where vi = ion-selective.
