BIOLOGY 3UU3 Lecture Notes - Genomic Imprinting, Mecp2, Demethylation
9 Feb 2013
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Document Summary
Dnmt1 maintenance methylrtansferase (i. e. maintains but not est maternal imprint), absence results in global demethylation and embryonic lethality, dnmt1o responsible for maintaining, but not establishing maternal imprints expressed highly during developing embryo imprint on female germ line. Dnmt3l no dnmt activity on own but joins to dnmt3a/b to of non-cpg methylation in flied. Dna binding complex mecp1 defective in the methylation- mediated of genes and significant gene depression. Hypothesize that symptoms due to inadequate silencing of the. Mecp2 may have a function in the brain, not related to. Gene activation during development: dna methylation during development long term silencing of gene expression. Genomic imprinting and x-chromosome inactivation (x-inactivation): due to monoallelic gene expression expression of imprinted genes and x inactivation dictated in embryo by parental origin: dmnt1 and dmnt1o maintenance of imprinting and x-activation. Dna methylation aging and diet: hyper and hypomethylation been associated with aging hypermethylation of specific genes seen in aging individuals.
